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Cytotoxic Petrosiacetylenes from the Marine Sponge Petrosia sp.
Author(s) -
Lee YeonJu,
Yoo SuJung,
Kang Jong Soon,
Yun Jieun,
Shin Hee Jae,
Lee Jong Seok,
Lee HyiSeung
Publication year - 2013
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-012-3727-5
Subject(s) - sponge , stereochemistry , cytotoxicity , biology , cancer cell lines , cytotoxic t cell , chemistry , cancer cell , cancer , botany , biochemistry , genetics , in vitro
A novel petrosiacetylene analog (petrosiacetylene E) has been isolated from the Korean marine sponge Petrosia sp., along with petrosiacetylene A, B and C. Their structures were elucidated on the basis of spectroscopic methods and the stereochemistry of the new compound was determined by using the modified Mosher's method. Petrosiacetylene E showed higher cytotoxicity against five human cancer cell lines than petrosiacetylene A and B, presumably due to the additional hydroxy group located at C‐16.