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Fish Oil Supplementation Reduces Cachexia and Tumor Growth While Improving Renal Function in Tumor‐Bearing Rats
Author(s) -
Coelho Isabela,
Casare Fernando,
Pequito Danielle C. T.,
Borghetti Gina,
Yamazaki Ricardo K.,
Brito Gleisson A. P.,
Kryczyk Marcelo,
Fernandes Luiz Claudio,
Coimbra Terezila M.,
Fernandez Ricardo
Publication year - 2012
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-012-3715-9
Subject(s) - endocrinology , medicine , fish oil , renal function , reabsorption , chemistry , weanling , cachexia , kidney , biology , cancer , fishery , fish <actinopterygii>
The objective of the present work was to study the renal function of healthy and tumor‐bearing rats chronically supplemented with fish oil (FO), a source of n‐3 polyunsaturated fatty acids. Weanling male rats were divided in two groups, one control (C) and another orally supplemented for 70 days with FO (1 g/kg body weight). After this time, half the animals of each group were injected in the right flank with a suspension of Walker 256 tumor cells (W and WFO). The W group had less proteinemia reflecting cachectic proteolysis, FO reversed this fact. Tumor weight gain was also reduced in WFO. Glomerular filtration rate (GFR) was not different in FO or W compared to C, but was higher in WFO. Renal plasma flow (RPF) was higher in the FO supplemented groups. The W group had lower plasma osmolality than the C group, but FO supplementation resulted in normalization of this parameter. Fractional sodium excretion (FE Na+ ) of FO rats was similar to C. Proximal Na + reabsorption, evaluated by lithium clearance, was similar among the groups. Urinary thromboxane B 2 (TXB 2 ) excretion was lower in the supplemented groups. The number of macrophages in renal tissue was higher in W compared to C rats, but was lower in WFO rats compared to W rats. In conclusion, FO supplementation resulted in less tumor growth and cachexia, and appeared to be renoprotective, as suggested by higher RPF and GFR.