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Three New Fatty Acid Esters from the Mushroom Boletus pseudocalopus
Author(s) -
Kim Ki Hyun,
Choi Sang Un,
Lee Kang Ro
Publication year - 2012
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-012-3657-2
Subject(s) - mushroom , chemistry , fatty acid , boletus , moiety , fractionation , stereochemistry , organic chemistry , food science
A bioassay‐guided fractionation and chemical investigation of a MeOH extract of the Korean wild mushroom Boletus pseudocalopus resulted in the identification of three new fatty acid esters, named calopusins A–C ( 1–3 ), along with two known fatty acid methyl esters ( 4–5 ). These new compounds are structurally unique fatty acid esters with a 2,3‐butanediol moiety. Their structures were elucidated through 1D‐ and 2D‐NMR spectroscopic data and GC–MS analysis as well as a modified Mosher's method. The new compounds 1–3 showed significant inhibitory activity against the proliferation of the tested cancer cell lines with IC 50 values in the range 2.77–12.51 μM.