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Interleukin‐15 Affects Differentiation and Apoptosis in Adipocytes: Implications in Obesity
Author(s) -
Fuster Gemma,
Almendro Vanessa,
FontesOliveira Cibely Cristine,
Toledo Míriam,
Costelli Paola,
Busquets Sílvia,
LópezSoriano Francisco J.,
Argilés Josep M.
Publication year - 2011
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-011-3594-5
Subject(s) - adipocyte , microbiology and biotechnology , cytokine , adipose tissue , apoptosis , mapk/erk pathway , medicine , endocrinology , cell growth , interleukin 6 , cellular differentiation , stat5 , biology , chemistry , signal transduction , immunology , biochemistry , gene
Interleukin‐15 (IL‐15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL‐15 on adipocyte differentiation using the 3T3‐L1 preadipose cell line. The data show that IL‐15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL‐15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL‐15). In conclusion, using the 3T3‐L1 adipocyte cell line, the results presented here show that IL‐15 exerts important effects on differentiation, proliferation and apoptosis. Altogether, the results presented here reinforce the idea that IL‐15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies.