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Enhanced Bioavailability of Eicosapentaenoic Acid from Fish Oil After Encapsulation Within Plant Spore Exines as Microcapsules
Author(s) -
Wakil Ammar,
Mackenzie Grahame,
DiegoTaboada Alberto,
Bell J. Gordon,
Atkin Stephen L.
Publication year - 2010
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-010-3427-y
Subject(s) - bioavailability , eicosapentaenoic acid , fish oil , chemistry , food science , chromatography , ethyl ester , fish <actinopterygii> , organic chemistry , pharmacology , polyunsaturated fatty acid , fatty acid , biology , fishery
Benefits of eicosapentaenoic acid (EPA) can be enhanced by raising their bioavailability through microencapsulation. Pollen can be emptied to form hollow shells, known as exines, and then used to encapsulate material, such as oils in a dry powder form. Six healthy volunteers ingested 4.6 g of fish oil containing 20% EPA in the form of ethyl ester first alone and then as 1:1 microencapsulated powder of exines and fish oil. Serum bioavailability of EPA was measured by area under curve (AUC 0–24 ). The mean AUC 0–24 of EPA from ethyl ester with exine ( M = 19.7, SD = 4.3) was significantly higher than ethyl ester without exines ( M = 2, SD = 1.4, p < 0.01).The bioavailability of EPA is enhanced by encapsulation by pollen exines.