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The Hypolipidemic Effect of an Ethyl Ester of Algal‐Docosahexaenoic Acid in Rats Fed a High‐Fructose Diet
Author(s) -
Ryan Alan S.,
BaileyHall Eileen,
Nelson Edward B.,
Salem Norman
Publication year - 2009
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-009-3330-6
Subject(s) - docosahexaenoic acid , eicosapentaenoic acid , clinical chemistry , hypertriglyceridemia , lipidology , food science , corn oil , fructose , fatty acid , biology , biochemistry , triglyceride , chemistry , medicine , cholesterol , polyunsaturated fatty acid
Preclinical and clinical studies demonstrate that the omega‐3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) as a triacylglycerol (TAG) or an ethyl ester are protective against cardiovascular disease. Both have significant TAG‐lowering effects. We developed a concentrated ethyl ester of DHA (MATK‐90, 900 mg/g) using microalgae as its source. This study evaluated the effects that different doses of MATK‐90 had on lipid levels and clinical parameters in male Wistar rats fed a high‐fructose diet used to induce hypertriglyceridemia (TAG ≥ 300 mg/dL). Effects of MATK‐90 were compared to those produced by a pharmaceutical product (Lovaza, formerly Omacor, P‐OM3; 465 mg EPA + 375 mg DHA), a TAG oil used in food (DHASCO, algal‐DHA, 40% DHA by weight), and a control (corn oil). Doses of MATK‐90 (0.6, 1.3, 2.5, 5.0 g kg −1 day −1 ), algal‐DHA (2 g DHA kg −1 day −1 ), and P‐OM3 (5.0 g kg −1 day −1 ) were administered by oral gavage for 28 days. A significant dose‐related decrease was observed in TAG and cholesterol levels in all but the lowest dose of MATK‐90 treatment group vs. control. The high‐dose group of MATK‐90 and the P‐OM3 group produced similar reductions in TAG levels.