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Plasma Lipid Levels of Rats Fed a Diet Containing Pork Fat as a Source of Lipids after Splenic Surgery
Author(s) -
Dinis Ana Paula Gonçalves,
Marques Ruy Garcia,
Simões Fernanda Correia,
Diestel Cristina Fajardo,
Caetano Carlos Eduardo Rodrigues,
Secchin Dióscuro José Ferreira,
Neto José Firmino Nogueira,
Portela Margareth Crisóstomo
Publication year - 2009
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-009-3302-x
Subject(s) - lipidology , clinical chemistry , very low density lipoprotein , spleen , medicine , endocrinology , cholesterol , lipid metabolism , lipid profile , autotransplantation , lipoprotein , blood lipids , high density lipoprotein , chemistry , transplantation
Experimental studies have suggested an important role of the spleen in lipid metabolism, although with controversial results. Our purpose was to analyze the effect of a nutritionally balanced (NB) diet and a diet containing pork fat (PF) as source of lipids on the lipid profile of rats submitted to splenic surgery. Sixty adult male Wistar rats were divided into six groups of 10 animals each: 1 sham‐operated, NB diet; 2 sham‐operated, PF diet; 3 total splenectomy (TS), NB diet; 4 TS, PF diet; 5 TS followed by splenic autotransplantation (SA), NB diet; and 6 SA, PF diet. Blood samples were collected at the beginning (D0) and after 12 weeks of the experiment (D + 12) for plasma lipid determination. Morphologic regeneration of splenic tissues was observed, with no differences between groups 5 and 6. When D + 12 plasma lipid levels were compared to D0 levels there were no differences in groups 1, 3, and 5, while in groups 2, 4, and 6 total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and triacylglycerols (TAG) increased, and high density lipoprotein (HDL) decreased. At D + 12, groups 2, 4, and 6 had lower HDL than group 3. In conclusion, regardless of the surgical procedure applied to the spleen, an NB diet maintained plasma lipid levels while a diet with PF as source of lipids changed the animals’ lipid profile.