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Abies koreana Essential Oil Inhibits Drug‐Resistant Skin Pathogen Growth and LPS‐Induced Inflammatory Effects of Murine Macrophage
Author(s) -
Yoon WeonJong,
Kim SangSuk,
Oh TaeHeon,
Lee Nam Ho,
Hyun ChangGu
Publication year - 2009
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-009-3297-3
Subject(s) - propionibacterium acnes , staphylococcus epidermidis , microbiology and biotechnology , acne , pathogenic bacteria , tumor necrosis factor alpha , anti inflammatory , staphylococcus aureus , macrophage , essential oil , biology , bacteria , pharmacology , chemistry , immunology , food science , biochemistry , in vitro , genetics
Abstract Since acne vulgaris is the combined result of a bacterial infection and the inflammatory response to that infection, we examined whether Abies koreana essential oil (AKE) possessed anti‐inflammatory and antibacterial activities against skin pathogens. In this study, AKE showed excellent antibacterial activities against drug‐susceptible and ‐resistant Propionibacterium acnes and Staphylococcus epidermidis , which are acne‐causing bacteria. In addition, AKE reduced the LPS‐induced secretion of tumor necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), IL‐6, NO and PGE 2 in RAW 264.7 cells, indicating that it has anti‐inflammatory effects. Therefore, we suggest that AKE may be an attractive candidate for promoting skin health.