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Dietary Marine‐Derived Tocopherol has a Higher Biological Availability in Mice Relative to Alpha‐Tocopherol
Author(s) -
Gotoh Naohiro,
Watanabe Hiroyuki,
Oka Tomiko,
Mashimo Daisuke,
Noguchi Noriko,
Hata Kazuhiko,
Wada Shun
Publication year - 2009
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-008-3257-3
Subject(s) - tocopherol , vitamin e , alpha tocopherol , clinical chemistry , lipidology , chemistry , biochemistry , antioxidant
The biologic availability of two kinds of tocomonoenols, marine‐derived tocopherol (MDT) and α‐tocomonoenol, was investigated in ICR mice. Vitamin E‐deficient ICR mice were fed MDT and α‐tocomonoenol together with α‐tocopherol, β‐tocopherol, γ‐tocopherol, and δ‐tocopherol, and storage in liver, spleen, lung, and brain was quantified using reverse‐phase high‐performance liquid chromatography. The vitamin E relative biologic availability (VE‐RBA) in liver was 100 for α‐tocopherol, 26 ± 3 for β‐tocopherol, 4 ± 2 for γ‐tocopherol, not detected for δ‐tocopherol, 49 ± 6 for MDT, and 30 ± 7 for α‐tocomonoenol. The VE‐RBA in brain was 100 for α‐tocopherol, 5 ± 2 for β‐tocopherol, not detected for γ‐tocopherol and δ‐tocopherol, 8 ± 1 for MDT, and 4 ± 1 for α‐tocomonoenol. Tocopherols and tocomonoenols did not accumulate in the spleen or lung. MDT and α‐tocomonoenol had high VE‐RBA values. The VE‐RBA value for MDT was much higher than that for β‐tocopherol.