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Dietary Conjugated Linoleic Acid Renal Benefits and Possible Toxicity vary with Isomer, Dose and Gender in Rat Polycystic Kidney Disease
Author(s) -
Ogborn Malcolm R.,
Nitschmann Evan,
Goldberg Aviva,
BankovicCalic Neda,
Weiler Hope A.,
Aukema Harold M.
Publication year - 2008
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-008-3211-4
Subject(s) - conjugated linoleic acid , endocrinology , medicine , kidney , clinical chemistry , lipidology , offspring , polycystic kidney disease , kidney disease , creatinine , fibrosis , adipose capsule of kidney , toxicity , biology , linoleic acid , fatty acid , chemistry , biochemistry , pregnancy , genetics
Conjugated linoleic acid (CLA) is anti‐proliferative and anti‐inflammatory in the Han:SPRD ‐cy rat model of kidney disease. We used different doses of CLA and examined effects on renal histological benefit, the renal PPARγ system and hepatic and renal levels of CLA isomers. Male and female offspring of Han:SPRD ‐cy heterozygotes were fed diets with 0, 1 or 2% CLA isomer mixture for 12 weeks before dual‐energy X‐ray absorptiometry, harvest of renal and hepatic tissue for histologic and lipid analysis. Both CLA diets reduced body fat content in both genders but did not change lean body mass. CLA produced a dose dependent reduction in female renal cystic change. CLA reduced fibrosis, but this reduction was significantly less with higher dose in males. CLA reduced macrophage infiltration, tissue oxidized LDL content and proliferation of epithelial cells. Serum creatinine rose significantly in female animals fed CLA diets. CLA treatment did not change PPARγ activation. A significant negative correlation with renal content of the 18:2 c9,t11 isomer and the sum of histologic effects was identified. CLA reduces histologic renal injury in the Han:SPRD ‐cy rat model probably inversely proportionate to c9,t11 renal content. Possible functional CLA toxicity at high dose in female animals warrants further exploration.