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Hepatic Lipase Gene −514 C / T Polymorphism in the Guangxi Hei Yi Zhuang and Han Populations
Author(s) -
Wu Jinzhen,
Yin Ruixing,
Lin Weixiong,
Pan Shangling,
Yang Dezhai
Publication year - 2008
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-008-3204-3
Subject(s) - genotype , hepatic lipase , medicine , triglyceride , allele , han chinese , lipidology , polymorphism (computer science) , genotyping , gene polymorphism , alcohol consumption , biology , clinical chemistry , chemistry , gene , genetics , cholesterol , alcohol , single nucleotide polymorphism , biochemistry
Hei Yi Zhuang is an isolated subgroup of the Zhuang minority in China. This study was designed to compare the difference in the hepatic lipase gene ( LIPC ) −514 C / T polymorphism and its association with lipid profiles between the Guangxi Hei Yi Zhuang and Han populations. Genotyping of the LIPC −514 C / T was performed in 873 subjects of Hei Yi Zhuang and 867 participants of Han Chinese. The frequency of −514 T allele was 43.47% in Hei Yi Zhuang, and 36.10% in Han ( P < 0.001). The frequencies of CC , CT and TT genotypes were 30.01, 53.04 and 16.95% in Hei Yi Zhuang, and 40.95, 45.91 and 13.14% in Han ( P < 0.001); respectively. Serum high‐density lipoprotein cholesterol (HDL‐C) and apolipoprotein B levels in both ethnic groups were higher in LIPC −514 T carriers than in C carriers. In addition, serum triglyceride levels in Han were higher in TT genotype individuals than in CC genotype subjects ( P < 0.05). Serum HDL‐C levels were positively correlated with age, alcohol consumption and LIPC −514 C / T genotypes, and negatively associated with hypertension and cigarette smoking in Hei Yi Zhuang ( P < 0.05–0.01), whereas HDL‐C levels were positively correlated with age, alcohol consumption and LIPC −514 C / T genotypes, and negatively associated with body mass index and cigarette smoking in Han ( P < 0.05–0.001). The differences in serum HDL‐C levels between the two ethnic groups might partially attribute to the differences in the LIPC −514 C / T polymorphism.