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A Pivotal Role of the Human Kidney in Catabolism of HDL Protein Components Apolipoprotein A‐I and A‐IV but not of A‐II
Author(s) -
Graversen Jonas Heilskov,
Castro Graciela,
Kandoussi Abdelmejid,
Nielsen Henning,
Christensen Erik Ilsø,
Norden Anthony,
Moestrup Søren Kragh
Publication year - 2008
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-008-3169-2
Subject(s) - apolipoprotein b , medicine , endocrinology , kidney , catabolism , excretion , clinical chemistry , chemistry , reabsorption , renal physiology , urinary system , cholesterol , urine , metabolism , biology
Renal handling of major HDL components was studied by analyzing urine from patients with Fanconi syndrome, a rare renal proximal tubular reabsorption failure, including dysfunction of the kidney HDL receptor, cubilin. A high urinary excretion of apolipoprotein A‐I and A‐IV corresponding to a major part of the metabolism of these proteins was measured. In contrast, no urinary excretion of apolipoprotein A‐II which is more hydrophobic and tighter bound to HDL was found. Control urines displayed absence of the three apolipoproteins. Urinary excretion of phospholipids, triglycerides, cholesterol and cholesterol esters in patients was as low as in controls. In conclusion, these data indicate that the human kidney is a major site for filtered nascent apolipoprotein A‐I and A‐IV but not for HDL particles.