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Identification of Lysophosphatidylcholine–Chlorohydrin in Human Atherosclerotic Lesions
Author(s) -
Messner M. C.,
Albert C. J.,
McHowat J.,
Ford D. A.
Publication year - 2008
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-008-3151-z
Subject(s) - lysophosphatidylcholine , lipidology , clinical chemistry , chemistry , medicine , biochemistry , biology , phosphatidylcholine , phospholipid , membrane
Lysophosphatidylcholine (LysoPtdCho) levels are elevated in sera in patients with atherosclerosis and in atherosclerotic tissue. Previous studies have shown that reactive chlorinating species attack plasmalogens in human coronary artery endothelial cells (HCAEC), forming lysoPtdCho and lysoPtdCho–chlorohydrin (lysoPtdCho–ClOH). The results herein demonstrate for the first time that lysoPtdCho–ClOH is elevated over 60‐fold in human atherosclerotic lesions. In cultured HCAEC, 18:0 lysoPtdCho–ClOH led to a statistically significant increase in P‐selectin cell‐surface expression, but unlike 18:1 lysoPtdCho did not lead to cyclooxygenase‐2 protein expression. These data show that 18:0 lysoPtdCho–ClOH is elevated in atherosclerotic tissue and may have unique pro‐atherogenic properties compared to lysoPtdCho.