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Brachial Artery Intima‐Media Thickness and Echogenicity in Relation to Lipids and Markers of Oxidative Stress in Elderly Subjects:‐The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study
Author(s) -
Lind Lars,
Andersson Jessika,
Rönn Monika,
Gustavsson Thomas,
Holdfelt Peter,
Hulthe Johannes,
Elmgren Anders,
Zilmer Kersti,
Zilmer Mihkel
Publication year - 2008
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-007-3125-6
Subject(s) - medicine , brachial artery , oxidative stress , echogenicity , intima media thickness , endocrinology , tunica media , cholesterol , population , cardiology , ultrasound , blood pressure , radiology , carotid arteries , environmental health
The aim of the present study was to relate brachial artery intima‐media thickness (IMT) and the grey scale median of the intima‐media complex (IM‐GSM) to traditional cardiovascular risk factors and markers of inflammation and oxidative stress. In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, a population‐based study of 1016 subjects aged 70, brachial artery IMT and IM‐GSM, who were evaluated by ultrasound. Lipids, thirteen markers of inflammation and nine markers of oxidative stress were measured. The Framingham risk score was related to IMT ( p < 0.0001), but not to the IM‐GSM. In univariate analysis, HDL‐cholesterol, serum triglycerides, fasting glucose, smoking, HOMA insulin resistance index and oxidized LDL levels were related to IMT. HDL and LDL‐cholesterol, triglycerides, VCAM‐1, e‐selectin, leukocyte count, conjugated diens, baseline conjugated diens (BCD)‐LDL, antibodies to oxLDL, the GSSG/GSH glutathione ratio and homocysteine were related to IM‐GSM. In multiple regression models, HDL‐cholesterol, fasting glucose and oxLDL levels were the independently related to IMT ( p = 0.01–0.04), while serum triglycerides, BCD‐LDL and the GSSG/GSH ratio were independently related to IM‐GSM ( p = 0.0001–0.004). In conclusion, in addition to traditional lipid variables, markers of oxidative stress were associated with both thickness and echogenicity of the brachial artery intima‐media complex. Thus, both thickness and echogenicity of the brachial artery intima‐media complex might be useful biomarkers in the future.