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New Sphingolipids with a Previously Unreported 9‐Methyl‐C 20 ‐sphingosine Moiety from a Marine Algous Endophytic Fungus Aspergillus niger EN‐13
Author(s) -
Zhang Yi,
Wang Song,
Li XiaoMing,
Cui ChuanMing,
Feng Chao,
Wang BinGui
Publication year - 2007
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-007-3079-8
Subject(s) - moiety , aspergillus niger , glycosphingolipid , stereochemistry , sphingolipid , sphingosine , candida albicans , ceramide , fungus , biology , chemistry , biochemistry , microbiology and biotechnology , botany , apoptosis , receptor
Asperamides A ( 1 ) and B ( 2 ), a sphingolipid and their corresponding glycosphingolipid possessing a hitherto unreported 9‐methyl‐C 20 ‐sphingosine moiety, were characterized from the culture extract of Aspergillus niger EN‐13, an endophytic fungus isolated from marine brown alga Colpomenia sinuosa . The structures were elucidated by spectroscopic and chemical methods as (2 S ,2′ R ,3 R ,3′ E ,4 E ,8 E )‐ N ‐(2′‐hydroxy‐3′‐hexadecenoyl)‐9‐methyl‐4,8‐icosadien‐1,3‐diol ( 1 ) and 1‐ O ‐β‐ d ‐glucopyranosyl‐( 2S , 2′R , 3R , 3′E , 4E , 8E )‐ N ‐(2′‐hydroxy‐3′‐hexadecenoyl)‐9‐methyl‐4,8‐icosadien‐1,3‐diol ( 2 ). In the antifungal assay, asperamide A ( 1 ) displayed moderate activity against Candida albicans .