New Sphingolipids with a Previously Unreported 9‐Methyl‐C 20 ‐sphingosine Moiety from a Marine Algous Endophytic Fungus  Aspergillus niger  EN‐13 | Zendy

Zhang Yi | Zendy; Wang Song | Zendy; Li XiaoMing | Zendy; Cui ChuanMing | Zendy; Feng Chao | Zendy; Wang BinGui | Zendy

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New Sphingolipids with a Previously Unreported 9‐Methyl‐C 20 ‐sphingosine Moiety from a Marine Algous Endophytic Fungus Aspergillus niger EN‐13

Author(s) -

Zhang Yi,

Wang Song,

Li XiaoMing,

Cui ChuanMing,

Feng Chao,

Wang BinGui

Publication year - 2007

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/s11745-007-3079-8

Subject(s) - moiety , aspergillus niger , glycosphingolipid , stereochemistry , sphingolipid , sphingosine , candida albicans , ceramide , fungus , biology , chemistry , biochemistry , microbiology and biotechnology , botany , apoptosis , receptor

Asperamides A ( 1 ) and B ( 2 ), a sphingolipid and their corresponding glycosphingolipid possessing a hitherto unreported 9‐methyl‐C 20 ‐sphingosine moiety, were characterized from the culture extract of Aspergillus niger EN‐13, an endophytic fungus isolated from marine brown alga Colpomenia sinuosa . The structures were elucidated by spectroscopic and chemical methods as (2 S ,2′ R ,3 R ,3′ E ,4 E ,8 E )‐ N ‐(2′‐hydroxy‐3′‐hexadecenoyl)‐9‐methyl‐4,8‐icosadien‐1,3‐diol ( 1 ) and 1‐ O ‐β‐ d ‐glucopyranosyl‐( 2S , 2′R , 3R , 3′E , 4E , 8E )‐ N ‐(2′‐hydroxy‐3′‐hexadecenoyl)‐9‐methyl‐4,8‐icosadien‐1,3‐diol ( 2 ). In the antifungal assay, asperamide A ( 1 ) displayed moderate activity against Candida albicans .

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