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Rumenic Acid Significantly Reduces Plasma Levels of LDL and Small Dense LDL Cholesterol in Hamsters Fed a Cholesterol‐ and Lipid‐Enriched Semi‐Purified Diet
Author(s) -
LeDoux Martial,
Laloux Laurent,
Fontaine JeanJacques,
Carpentier Yvon A.,
Chardigny JeanMichel,
Sébédio JeanLouis
Publication year - 2007
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-007-3023-y
Subject(s) - conjugated linoleic acid , cholesterol , lipidology , clinical chemistry , chemistry , linoleic acid , hamster , apolipoprotein b , lipoprotein , medicine , food science , endocrinology , fatty acid , biochemistry , biology
Conjugated linoleic acids (CLAs) consist of a series of positional and geometrical isomers of linoleic acid. CLA have been reported to beneficially affect cardiovascular risk factors in animal models. In order to assess the role of individual CLA isomers on lipoprotein cholesterol concentration, 30 hamsters were fed for 12 weeks an hyperlipidic diet containing pure cis ‐9, trans ‐11 CLA ( c 9, t 11) or pure trans ‐10, cis ‐12 CLA ( t 10, c 12) isomers given alone or as a mixture. Plasma total cholesterol, LDL and HDL cholesterol concentrations were significantly lower in the c 9, t 11 CLA isomer fed hamsters relative to the Control group, with the most substantially effect on LDL cholesterol (−56%; P < 0.05). Plasma triacylglycerol concentrations did not differ significantly regarding those two groups. Plasma cholesterol parameters showed a tendency to decrease in the t 10, c 12 CLA isomer and CLA mixture fed hamsters compared with the Control group, but differences were not significant. For the first time, the atherogenic fraction of small dense LDL was investigated. Plasma small dense LDL cholesterol concentration was lower in the c 9, t 11 CLA relative to Control, while the t 10, c 12 and CLA mixture groups showed only a non significant tendency to decrease. Taken together, these data indicate that feeding rumenic acid ( c 9, t 11 CLA) may beneficially affect lipoprotein profile in hamster fed a cholesterol‐ and lipid‐enriched semi‐purified diet, when t 10, c 12 CLA isomer or CLA mixture would be less active.