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Dietary comparison of conjugated linolenic acid (9 cis , 11 trans , 13 trans ) and α‐tocopherol effects on blood lipids and lipid peroxidation in alloxan‐induced diabetes mellitus in rats
Author(s) -
Dhar P.,
Bhattacharyya D.,
Bhattacharyya D. K.,
Ghosh S.
Publication year - 2006
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-006-5069-7
Subject(s) - lipid peroxidation , alloxan , tocopherol , chemistry , sunflower oil , antioxidant , medicine , diabetes mellitus , cholesterol , clinical chemistry , endocrinology , linolenic acid , biochemistry , vitamin e , fatty acid , linoleic acid
The present study investigated the dietary effect of conjugated linolenic acid (CLnA) on lipid profiles and lipid peroxidations in alloxan‐induced diabetes mellitus in rats. Diabetic rats were fed with 20% sunflower oil (diabetic control), sunflower oil supplemented with 0.5% CLnA, sunflower oil supplemented with 0.15% α‐tocopherol, and sunflower oil containing 0.25% CLnA+0.15% α‐tocopherol. The results demonstrated that 0.5% CLnA, 0.15% α‐tocopherol, and 0.25% CLnA+0.15% α‐tocopherol each on supplementation significantly lowered total cholesterol and non‐HDL‐cholesterol in comparison with the diabetic control group. The TAG level was significantly lowered in both the 0.15% α‐tocopherol and 0.25% CLnA+0.15% α‐tocopherol groups. LDL lipid peroxidation and erythrocyte membrane lipid peroxidation were reduced significantly in each of the experimental groups vs. the control group. The CLnA+α‐tocopherol diet induced a greater reduction in membrane lipid and liver lipid peroxidation than the α‐tocopherol diet alone. In conclusion, dietary CLnA exerts antioxidant activity as evidenced by reduced lipid peroxidation in chemically induced diabetes mellitus.