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Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal gender
Author(s) -
Ogborn Malcolm R.,
Nitschmann Evan,
BankovicCalic Neda,
Weiler Hope A.,
Aukema Harold M.
Publication year - 2006
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-006-5064-z
Subject(s) - polycystic kidney disease , medicine , endocrinology , lipidology , clinical chemistry , kidney , inflammation , autosomal dominant polycystic kidney disease , kidney disease , nephrology
Flaxseed derivatives, including both oil and flax lignan, modify progression of renal injury in animal models, including Han:SPRD‐ cy polycystic kidney disease (PKD). Gender is a significant factor in the rates of progression of many forms of human renal disease, but the role of gender in the response to nutrition intervention in renal disease is unexplored. In this study, male and female Han:SPRD‐ cy rats or normal littermates were fed either corn oil (CO) or flax oil (FO) diets, with or without 20 mg/kg of the diet flax lignan secoisolaricinoresinol dyglycoside (SDG). Renal injury was assessed morphometrically and biochemically. Renal and hepatic PUFA composition was assessed by GC and renal PGE 2 release by ELISA. FO preserved body weight in PKD males, with no effect in females. SDG reduced weight in both normal and PKD females. FO reduced proteinuria in both male and female PKD. FO reduced cystic change and renal inflammation in PKD males but reduced cystic change, fibrosis, renal inflammation, tissue lipid peroxides, and epithelial proliferation in PKD females. SDG reduced renal inflammation in all animals and lipid peroxides in PKD fenales. A strong interaction between SDG and FO was observed in renal FA composition of female kidneys only, suggesting increased conversion of C 18 PUFA to C 20 PUFA. FO reduced renal release of PGE 2 in both genders. Gender influences the effects of flaxseed derivatives in Han:SPRD‐ cy rats. Gender‐based responses to environmental factors, such as dietary lipid sources and micronutrients, may contribute to gender‐based differences in disease progression rates.