Premium
Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high‐fat ketogenic diet does not inhibit carbon recycling of 13 C‐α‐linolenate
Author(s) -
Taha Ameer Y.,
Ryan Mary Ann,
Cunnane Stephen C.
Publication year - 2006
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-006-5046-1
Subject(s) - lipidology , clinical chemistry , ketogenic diet , linolenate , food science , chemistry , carbon fibers , fatty acid , medicine , endocrinology , organic chemistry , biochemistry , materials science , composite material , composite number , epilepsy , psychiatry
Under various dietary and physiological conditions, carbon from α‐linolenic acid (ALA) is extensively recycled into saturated and monounsaturated fatty acids. In this study we investigated whether carbon is still recycled from ALA when a dietary source of saturated and monounsaturated fatty acids is provided in excess. 13 C‐labeled ALA was given to rats consuming a high‐fat ketogenic diet and to rats consuming a low‐fat control diet. In rats on the ketogenic diet, 13 C recycling from α‐linolenate into several, but not all, saturated and monounsaturated fatty acids matched or exceeded that in the controls (P<0.05). We conclude that carbon recycling into saturated and monounsaturated fatty acids persists when the main end products of ALA recycling are provided in excess, using a ketogenic diet.