Butters Varying in  trans  18:1 and  cis ‐9, trans‐ 11 Conjugated Linoleic Acid Modify Plasma Lipoproteins in the Hypercholesterolemic Rabbit | Zendy

Bauchart Dominique | Zendy; Roy Alexandre | Zendy; Lorenz Stephanie | Zendy; Chardigny JeanMichel | Zendy; Ferlay Anne | Zendy; Gruffat Dominique | Zendy; Sébédio JeanLouis | Zendy; Chilliard Yves | Zendy; Durand Denys | Zendy

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Butters Varying in trans 18:1 and cis ‐9, trans‐ 11 Conjugated Linoleic Acid Modify Plasma Lipoproteins in the Hypercholesterolemic Rabbit

Author(s) -

Bauchart Dominique,

Roy Alexandre,

Lorenz Stephanie,

Chardigny JeanMichel,

Ferlay Anne,

Gruffat Dominique,

Sébédio JeanLouis,

Chilliard Yves,

Durand Denys

Publication year - 2007

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/s11745-006-3018-0

Subject(s) - conjugated linoleic acid , very low density lipoprotein , lipidology , chemistry , apolipoprotein b , clinical chemistry , medicine , endocrinology , cholesterol , lipoprotein , radial immunodiffusion , low density lipoprotein , linoleic acid , biochemistry , fatty acid , biology , antibody , immunology

The experiment was designed to study the effects of butters differing in conjugated linoleic acid (CLA) and trans 18:1 contents on lipoproteins associated with the risk of atherogenesis. New Zealand White male rabbits (9.6 weeks; 2.1 kg) were assigned for 6 or 12 weeks to three diets ( n = 6 per diet) made of conventional pellets with 0.2% cholesterol and with 12% fat provided from a butter poor in trans ‐10 and trans ‐11 18:1 and in CLA (standard group), or rich in trans‐ 10 18:1 ( trans ‐10 18:1 group) or rich in trans ‐11 18:1 and in cis ‐9, trans ‐11 CLA ( trans ‐11 18:1/CLA group). Blood samples were collected at the end of dietary treatments. Lipoproteins were separated by gradient‐density ultracentrifugation. Lipid classes were determined enzymatically and apolipoproteins A‐I and B by radial immunodiffusion. Mainly in the 12‐week rabbits, higher plasma triglycerides and apolipoprotein B levels shown in the standard and trans ‐10 18:1 groups compared with those in the trans ‐11 18:1/CLA group are associated with higher plasma levels of very low density lipoproteins (VLDL) and low density lipoproteins (LDL) also shown in these two groups. In the 12‐week rabbits, a shift towards denser LDL, considered as more atherogenic, was shown only in the trans ‐10 18:1 group. In these animals, the VLDL + LDL to HDL ratio was 1.7–2.3 times higher in the trans ‐10 18:1 group than in the other groups ( P = 0.076). These results suggest a rather neutral effect of trans ‐11 18:1/CLA butter towards the risk of atherogenesis, whereas trans ‐10 18:1 butter would tend to be detrimental.

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