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Remote functionalization of the steroid side‐chain
Author(s) -
Parish Edward J.,
Aksara Nida,
Boos Terrence L.
Publication year - 1997
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-006-0171-4
Subject(s) - side chain , steroid , chemistry , surface modification , combinatorial chemistry , side effect (computer science) , organic chemistry , computer science , biochemistry , polymer , hormone , programming language
By using classical methods of organic synthesis, the introduction of chemical modifications into the saturated sidechains of steroids usually requires a multistep synthesis to construct new side‐chains to be added to the steroid nucleus. In order to circumvent these earlier methods, new procedures have been developed to directly introduce functionality onto the steroid side‐chain to produce useful products. These initial products may also provide an entry toward the further modification of the side‐chain to produce steroids which could previously be obtained only with great difficulty.