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Synthesis and characterization of a series of carbamate‐linked cationic lipids for gene delivery
Author(s) -
Liu Dongliang,
Hu ianjun,
Qiao Weihong,
Li Zongshi,
Zhan Shubiao,
Cheng Lvbo
Publication year - 2005
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-005-1446-5
Subject(s) - lipidology , carbamate , cationic polymerization , characterization (materials science) , chemistry , series (stratigraphy) , gene delivery , clinical chemistry , biochemistry , gene , organic chemistry , biology , nanotechnology , genetic enhancement , materials science , paleontology
Abstract A series of pH‐sensitive lipids, 1a‐h [(2,3‐bis‐alkyl‐carbamoyloxy‐propyl)‐trialkylammonium halide] and 2a‐d (1‐dimethylamino‐2,3‐bis‐alkylcarbamoyloxy‐propane), with carbamate linkages between the hydrocarbon chains and an ammonium or tertiary amine head, were synthesized for liposome‐mediated gene delivery. The variable length of the carbon chains and the quaternary ammonium or neutral tertiary amine heads allowed us to identify the structure‐function relationship showing how these factors would affect cationic lipid in gene delivery performance.