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Effect of cancer cachexia on triacylglycerol/fatty acid substrate cycling in white adipose tissue
Author(s) -
Beck S. A.,
Tisdale M. J.
Publication year - 2004
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-004-1346-8
Subject(s) - cachexia , adipose tissue , white adipose tissue , clinical chemistry , medicine , lipidology , endocrinology , glycerol , in vivo , cancer , chemistry , biology , biochemistry , microbiology and biotechnology
The effect of cancer cachexia on the TAG/FA substrate cycle in white adipose tissue was determined in vivo using the MAC16 murine model of cachexia. When compared with non‐tumor‐bearing animals, the rate of TAG‐glycerol production was found to be increased almost threefold in animals bearing the MAC13 tumor, which does not induce cachexia, but was not further elevated in animals bearing the MAC16 tumor. In both cases TAG‐glycerol production and de novo synthesis of TAG‐FA were also increased above non‐tumor‐bearing animals. In animals bearing the MAC16 tumor, the TAG‐FA rates were significantly higher than in animals bearing the MAC13 tumor. This suggests that the presence of the tumor alone is sufficient to cause an increase in cycling rate, and in the absence of an elevated energy intake (MAC16) this may contribute to the depletion of adipose tissue.

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