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Immunomodulation by polyunsaturated fatty acids: Impact on T‐cell signaling
Author(s) -
Stulnig Thomas M.,
Zeyda Maximilian
Publication year - 2004
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-004-1344-x
Subject(s) - lipidology , polyunsaturated fatty acid , clinical chemistry , chemistry , neurochemistry , biochemistry , food science , biology , fatty acid , neuroscience , neurology
Abstract In recent years the potential application of the immunomodulatory effects of polyunsaturated FA (PUFA), particularly those of the n−3 series, in a variety of inflammatory disorders has been of considerable interest. However, the mechanisms underlying inhibition of T‐cell activation have so far been unclear. In this short review we summarize possible mechanisms for the modulation of immune responses by PUFA. Effects of PUFA on T‐cell signal transduction pathways and underlying molecular mechanisms are described in detail. These recent results add considerably to the understanding of mechanisms of PUFA actions, but their relevance in the in vivo situation must still be elucidated.