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Rapid clearance of hexachlorobenzene from chylomicrons
Author(s) -
Jandacek Ronald J.,
Zheng Shuqin,
Yang Qing,
Iso Patrick
Publication year - 2004
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-004-1321-4
Subject(s) - hexachlorobenzene , chylomicron , triolein , chemistry , medicine , biochemistry , cholesterol , organic chemistry , lipoprotein , very low density lipoprotein , lipase , pollutant , enzyme
Toxic organochlorines that are present in food are lipophilic and carried by chylomicrons. We have studied the clearance of an organochlorine, hexachlorobenzene, from chylomicrons. Chylomicrons were obtained from mesenteric lymph of rats that were intraduodenally given 14 C‐hexachlorobenzene and 3 H‐triolein. The labeled chylomicrons were injected intravenously into recipient rats, and the clearance of isotopes was followed. Surprisingly, the hexachlorobenzene disappeared from the plasma more rapidly than the triolein. This unexpected result raises questions about the manner in which hexachlorobenzene is delivered to tissues. The tissue distribution of the hexachlorobenzene is consistent with its rapid uptake.