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Phospholipase D‐catalyzed synthesis of novel phospholipid‐phytosterol conjugates
Author(s) -
Hossen Monjur,
Hernandez Ernesto
Publication year - 2004
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-004-1295-2
Subject(s) - phytosterol , phospholipid , lipidology , chemistry , phospholipase d , conjugate , clinical chemistry , phospholipase , catalysis , biochemistry , residue (chemistry) , phospholipase a , phospholipase a2 , acylation , amphiphile , organic chemistry , enzyme , membrane , copolymer , polymer , mathematical analysis , mathematics
In the present study, plant sterols were modified to form amphiphiles by synthesizing phospholipid derivatives from them so they could be formulated in different functional foods and possibly improve their effects as therapeutic agents. The new phosphatidyl derivatives, phosphatidyl‐sitosterols, were synthesized by the transfer reaction of a phosphatidyl residue from PC to β‐sitosterol by phospholipase D (PLD EC 3.1.4.4) from Streptomyces sp. in a biphasic medium.