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8302A/C and (TTA)n polymorphisms in the HMG‐CoA reductase gene may be associated with some plasma lipid metabolic phenotypes in patients with coronary heart disease
Author(s) -
Tong Yu,
Zhang Sizhong,
Li Hai,
Su Zhiguang,
Kong Xiangdong,
Liu Hekun,
Xiao Cuiying,
Sun Yan,
Shi Jia Jun
Publication year - 2004
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-004-1225-3
Subject(s) - lipidology , clinical chemistry , genotype , reductase , medicine , allele , endocrinology , cholesterol , lipid metabolism , hydroxymethylglutaryl coa reductase , locus (genetics) , biology , hmg coa reductase , gene polymorphism , gene , phenotype , coronary heart disease , enzyme , genetics , biochemistry
HMG‐CoA reductase (HMGCR) is a rate‐limiting enzyme that participates in cholesterol metabolism. Here we analyzed the 8302A/C and the (TTA)n polymorphisms in the HMGCR gene in 169 Chinese patients with coronary heart disease (CHD) and 161 age‐matched controls. Results indicated that the levels of plasma VLDL and TG in patients with the AA genotype of the 8302A/C locus were significantly higher than in patients with other genotypes ( P <0.05). In addition, the frequency of allele A4 of the (TTA)n locus was higher ( P <0.05) and the frequency of allele A5 was lower ( P =0.002) in CHD patients than in the controls. This suggests that both polymorphisms in the HMGCR gene may be associated with lipid and lipoprotein abnormalities in CHD in the Chinese.