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n−3 long‐chain FA decrease serum levels of TG and remnant‐like particle‐cholesterol in humans
Author(s) -
Hamazaki Kei,
Itomura Miho,
Huan Mingming,
Nishizawa Hiroto,
Watanabe Shiro,
Hamazaki Tomohito,
Sawazaki Shigeki,
Terasawa Katsutoshi,
Nakajima Shuuji,
Terano Takashi,
Hata Yoshiya,
Fujishiro Seiichi
Publication year - 2003
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-003-1069-x
Subject(s) - medicine , fish oil , endocrinology , clinical chemistry , cholesterol , triglyceride , chemistry , blood lipids , lipidology , soybean oil , zoology , biology , fish <actinopterygii> , biochemistry , fishery
A large number of papers have reported that administration of n−3 FA reduced serum TG concentrations in hypertriglyceridemic patients. However, few studies have examined the effect of n−3 FA on serum concentrations of remnant‐like particle (RLP) cholesterol. Volunteers ( n =41) whose serum TG concentrations were 100–300 mg/dL were recruited and randomly assigned to either an n−3 FA group or a control group with stratification by sex, age, and serum TG level in a double‐blind manner. The subjects in the n−3 FA group were administered 125 ml of fermented soybean milk with fish oil containing 600 mg of EPA and 260 mg of DHA/d for 12 wk. The controls consumed control soybean milk with olive oil. Fasting blood samples were obtained before the start of administration and at 4, 8 and 12 wk. EPA concentrations in red blood cells increased significantly in all but one subject in the n−3 FA group, with no significant changes in the control group. TG levels decreased more in the n−3 FA group than in the control group at weeks 4 ( P <0.05), 8 ( P <0.01), and 12 ( P <0.05) with their baseline as covariate. RLP cholesterol levels decreased more in the n−3 FA group than in the control at weeks 8 ( P <0.01) and 12 ( P <0.05) with their baseline as covariate. The groups did not differ in the other lipid levels. It is likely that n−3 long‐chain FA may exert anti‐atherosclerotic effects by lowering serum TG and RLP‐cholesterol levels even at the dose of 860 mg/d.