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Whole‐body utilization of n−3 PUFA in n−6 PUFA‐deficient rats
Author(s) -
Bazinet Richard P.,
Douglas Holly,
Cunnane Stephen C.
Publication year - 2003
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-003-1050-8
Subject(s) - polyunsaturated fatty acid , clinical chemistry , lipidology , chemistry , long chain , food science , endocrinology , medicine , biology , biochemistry , fatty acid , polymer science
We evaluated the utilization of α‐linolenic acid (18∶3n−3) in growing rats consuming a diet deficient in n−6 PUFA. After 90 d, whole‐body 18∶3n−3 accumulation was 55% lower, total n−3 PUFA accumulation was 21% lower, and 18∶3n−3 disappearance was 14% higher in n−6 PUFA‐deficient rats. Part of the reduction of whole‐body 18∶3n−3 in n−6 PUFA‐deficient rats was due to the 25% increase in net conversion of 18∶3n−3 to long‐chain n−3 PUFA. Despite adequate 18∶3n−3 intake, n−6 PUFA deficiency decreased the accumulation of 18∶3n−3 and total n−3 PUFA.