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CLA and body weight regulation in humans
Author(s) -
Risérus Ulf,
Smedman Annika,
Basu Samar,
Vessby Bengt
Publication year - 2003
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-003-1043-7
Subject(s) - clinical chemistry , lipid metabolism , lipid peroxidation , lipidology , medicine , endocrinology , chemistry , metabolism , carbohydrate metabolism , insulin , biochemistry , biology , antioxidant
CLA comprises a group of unsaturated FA isomers with a variety of biological effects in experimental animals. CLA reduces body fat accumulation in animal models and has been suggested to have significant effects on lipid and glucose metabolism, e.g., antidiabetic effects in obese Zucker rats. It has been proposed that the trans 10‐ cis 12 isomer is the active isomer associated with the antiobesity and insulin‐sensitizing properties of CLA. The metabolic effects in humans in general, and isomer‐specific effects specifically, are not well characterized. In a series of controlled studies in humans, we investigated the effects of CLA (given as the commercially available mixture of isomers and as the purified trans 10‐ cis 12 CLA isomer) on anthropometry, lipid and glucose metabolism, and markers of lipid peroxidation. Preliminary results indicate that CLA may slightly decrease body fat in humans also, particularly abdominal fat, but there is no effect on body weight or body mass index. There is no simultaneous improvement in lipid or glucose metabolism. Rather, the trans 10‐ cis 12 CLA isomer unexpectedly caused significant impairment of the peripheral insulin sensitivity as well as of blood glucose and serum lipid levels. In addition, CLA markedly elevated lipid peroxidation. Thus, the metabolic effects of CLA in human seem complex; further studies, especially of isomer‐specific effects and for longer time periods, are warranted.