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Lauric acid is desaturated to 12∶1n−3 by hepatocytes and rat liver homogenates
Author(s) -
Legrand Philippe,
Catheline Daniel,
Rioux Vincent,
Durand Georges
Publication year - 2002
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-002-0934-y
Subject(s) - lauric acid , lipidology , clinical chemistry , biochemistry , biosynthesis , chemistry , hepatocyte , chromatography , fatty acid , biology , in vitro , enzyme
Lauric acid desaturation was investigated and described in liver homogenates and in cultured rat hepatocytes. The identification of the desaturated product of lauric acid has been performed using the oxidative cleavage method, and we showed that the obtained monoene was mainly 12∶1n−3. This result suggests that lauric acid desaturation could be the first step in the biosynthesis of α‐linolenic acid in animal cells.