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Exercise training‐induced changes in sensitivity to endothelin‐1 and aortic and cerebellum lipid profile in rats
Author(s) -
Latorre Eduardo,
Marán María,
Aragonés M. Dolores,
Saborido Ana,
Fernandez Inmaculada,
Delgado Jerónimo,
Catalan R. Edgardo,
Megías Alicia
Publication year - 2002
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-002-0862-x
Subject(s) - ceramide , endocrinology , medicine , cerebellum , clinical chemistry , aorta , endothelin 1 , chemistry , biochemistry , receptor , apoptosis
The purpose of this work was to study whether exercise training induces changes in the lipid profile of rat aorta and nervous system and in the in vitro intrinsic responsiveness of these tissues to endothelin‐1 (ET‐1) treatment. The exercise program performed successfully produced the characteristic metabolic alterations of the trained state. Exercise training induced a large and significant increase in the levels of both aortic ethanolamine plasmalogens (PlasEtn) and glucosylceramides. In contrast, a decrease of aortic ceramide and cholesterol levels was evoked by exercise training. ET‐1 increased PlasEtn content only in sedentary animals. An exercise‐induced increase in cerebellum levels of ceramides and ceramide monohexosides was found. The cerebellum ceramide content was increased by FT‐1 more noticeably in sedentary rats than in trained animals. In contrast, cerebral cortex was observed to be largely insensitive to both exercise training and ET‐1 treatment. It was concluded that exercise training (i) induces changes in both vascular and cerebellar lipid profiles, the former being much more pronounced than the latter, and (ii) diminishes the aortic and cerebellar sensitivity to ET‐1 action.