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β‐Oxidation of conjugated linoleic acid isomers and linoleic acid in rats
Author(s) -
Sergiel JeanPierre,
Chardigny JeanMichel,
Sébédio JeanLouis,
Berdeaux Olivier,
Juaneda Pierre,
Loreau Olivier,
Pasquis Bruno,
Noel JeanPierre
Publication year - 2001
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-001-0848-8
Subject(s) - conjugated linoleic acid , linoleic acid , lipidology , clinical chemistry , chemistry , food science , metabolism , biochemistry , fatty acid
To assess the oxidative metabolism of conjugated linoleic acid (CLA) isomers, rats were force‐fed 1.5–2.6 MBq of [1‐ 14 C]‐linoleic acid (9 c ,12 c ‐18∶2),‐rumenic acid (9 c ,11 t ‐18∶2), or‐10 trans , 12 cis ‐18∶2 (10 t , 12 c ‐18∶2), and 14 CO 2 production was monitored for 24 h. The animals were then necropsied and the radioactivity determined in different tissues. Both CLA isomers were oxidized significantly more than linoleic acid. Moreover, less radioactivity was recovered in most tissues after CLA intake than after linoleic acid intake. The substantial oxidation of CLA isomers must be considered when assessing the putative health benefits of CLA supplements.