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Effects of carp and tuna oils on 5‐fluorouracil‐induced antitumor activity and side effects in sarcoma 180‐bearing mice
Author(s) -
Kimura Yoshiyuki,
Takaku Takeshi,
Nakajima Shigeru,
Okuda Hiromichi
Publication year - 2001
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-001-0727-3
Subject(s) - tuna , carp , fish oil , chemistry , oral administration , toxicity , biology , pharmacology , fishery , fish <actinopterygii> , organic chemistry
In this study, we examined the effects of fish oils on 5‐fluorouracil (5‐FU)‐induced antitumor activity in mice. First, we examined the antitumor activity of the oral administration of two fish oils (carp oil and tuna oil) in sarcoma 180‐bearing mice. Carp oil (0.2 and 0.4 mL/mouse) and tuna oil (0.2 and 0.4 mL/mouse) had no effects on tumor growth. Next, we examined the combined effects of 5‐FU plus two fish oils (carp oil and tuna oil) on the antitumor activity and side effects compared to the effects of 5‐FU alone (12.5 mg/kg/d). We found that carp oil (0.4 mL/mouse) or tuna oil (0.2 or 0.4 mL/mouse) enhanced the ability of 5‐FU (12.5 mg/kg/d) to prevent tumor growth, without increasing side effects such as myelotoxicity and immunocompetent organ toxicity. Tuna oil (0.2 mL/mouse) slightly reduced body weight as compared to the effects of 5‐FU alone and water alone (control). The area under the curve (AUC) (0–120 min) of blood 5‐FU levels was reduced by the oral co‐administration of 5‐FU with carp oil or tuna oil. Apparent T max was shortened by the oral co‐administration of 5‐FU with carp oil or tuna oil. On the other hand, AUC (0–4 h) of 5‐FU incorporation into tumor RNA fraction was not affected by the oral co‐administration of 5‐FU with carp oil or tuna oil.