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Dietary supplementation with conjugated linoleic acid does not alter the resistance of mice to Listeria monocytogenes infection
Author(s) -
Turnock Lori,
Cook Mark,
Steinberg Howard,
Czuprynski Charles
Publication year - 2001
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-001-0699-3
Subject(s) - conjugated linoleic acid , listeria monocytogenes , clinical chemistry , biology , lipidology , immune system , immunity , microbiology and biotechnology , inflammation , linoleic acid , antimicrobial , clinical nutrition , food science , immunology , bacteria , biochemistry , endocrinology , fatty acid , genetics
Conjugated linoleic acid (CLA) has been used experimentally as a dietary supplement to increase lean body weight and to modulate inflammation in a variety of animal species. In addition, human use of dietary CLA as a supplement to regulate body fat has received both scientific and public attention. No reports have been published regarding the effects of dietary CLA on antimicrobial resistance. In this study, we provide evidence that feeding CLA for up to 4 wk does not alter host defense against Listeria monocytogenes in mice. These findings suggest that the anti‐inflammatory effects of CLA do not impair cellular immunity to this intracellular pathogen.