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n‐3 fatty acids: Antiatherosclerotic effects
Author(s) -
De Caterina Raffaele,
Zampolli Antonella
Publication year - 2001
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-001-0685-9
Subject(s) - lipidology , clinical chemistry , coronary heart disease , incidence (geometry) , coronary atherosclerosis , disease , medicine , food science , physiology , biology , chemistry , cardiology , physics , optics
The low incidence of cardiovascular disease associated epidemiologically with high consumption of food rich in n‐3 fatty acids suggests the possibility that part of the beneficial cardiovascular effects of these natural substances may be due to a reduction of atherosclerosis. This has been recently confirmed in autoptic data and in at least one prospective trial evaluating the progression of coronary atherosclerosis in humans. This paper reviews published literature on n‐3 fatty acids and atherosclerosis in animal models and in humans and in vitro experimental data yielding suport to the hypothesis of antiatherosclerotic effects of these substances.