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Protective effect of phytic acid hydrolysis products on iron‐induced lipid peroxidation of liposomal membranes
Author(s) -
Miyamoto Sayuri,
Kuwata Goro,
Imai Masatake,
Nagao Akihiko,
Terao Junji
Publication year - 2000
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-000-0659-y
Subject(s) - phytic acid , chemistry , lipid peroxidation , hydrolysis , liposome , chelation , biochemistry , inositol , antioxidant , inorganic chemistry , receptor
Beneficial effects of dietary phytic acid ( myo ‐inositol hexaphosphate; IP 6 ) have often been explained by its strong iron ion‐chelating ability, which possibly suppresses iron ion‐induced oxidative damage in the gastrointestinal tract. Because phytic acid is hydrolyzed during digestion, this work aimed to know whether its hydrolysis products (IP 2′ IP 3′ , IP 4′ and IP 5 ) could still prevent iron ion‐induced lipid peroxidation. Studies using liposomal membranes demonstrated that hydrolysis products containing three or more phosphate groups are able to inhibit iron ion‐induced lipid peroxidation although their effectiveness decreased with dephosphorylation. Similarly, they also prevented iron ion‐induced decomposition of phosphatidylcholine hydroperoxide. These results demonstrate that intermediate products of phytic acid hydrolysis still possess iron ion‐chelating ability, and thus they can probably prevent iron ion‐induced lipid peroxidation in biological systems.