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Application of Micellar Extraction for Isolation of Famotidine from Aqueous Samples Prior to its Chromatographic Determination
Author(s) -
KiszkielTaudul Ilona,
Starczewska Barbara,
Karpińska Joanna,
Kasabuła Monika
Publication year - 2017
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1007/s11743-017-2003-3
Subject(s) - chemistry , famotidine , chromatography , extraction (chemistry) , repeatability , detection limit , aqueous solution , calibration curve , pulmonary surfactant , salting out , medicine , biochemistry
Micellar extraction was applied to isolate famotidine from aqueous samples. This drug is an H 2 receptor antagonist used for the treatment of stomach diseases. The process was performed with a mixture of anionic sodium dodecylsulfate and nonionic Triton X‐114 surfactants. The effect of different parameters on the efficiency of the micellar extraction such as electrolyte and surfactant concentration, pH of sample, temperature, shaking and centrifugation time was investigated. The influence of foreign substances on a studied process was tested. The elaborated procedure was applied for HPLC–UV determination of famotidine in natural water samples. The calibration graph was recorded in the range 1.35–37.12 μg mL −1 of the studied compound. The repeatability of the method was equal to 7.4%. The limit of detection and quantification values for the determination of famotidine by using the proposed method amounted to 0.40 and 1.25 μg mL −1 , respectively.