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Effect of Amino Acids and Glycyl Dipeptides on Micellization of Antibacterial Drug Domiphen Bromide
Author(s) -
Yan Zhenning,
Kang Yunxia,
Wen Xiangli,
Xu Cuiying,
Chu Wenwen
Publication year - 2017
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1007/s11743-017-1925-0
Subject(s) - chemistry , dipeptide , bromide , glycylglycine , amino acid , aqueous solution , organic chemistry , inorganic chemistry , glycine , biochemistry
The effects of amino acids (glycine, l ‐alanine, l ‐valine, l ‐leucine) and glycyl dipeptides (glycylglycine, glycyl‐ l ‐valine, glycyl‐ l ‐leucine) on the micellization behaviour of antibacterial drug domiphen bromide in aqueous solution as a function of temperature were studied by both conductivity and fluorescence spectroscopy. Critical micellar concentration, degree of counterion dissociation ( α ), limiting molar conductivity ( Λ 0 ), and a series of thermodynamic parameters of micellization of domiphen bromide have been calculated from the specific conductivity data. The I 1 / I 3 ratios associated with pyrene fluorescence vibronic bands were used to interpret the variation of micropolarity caused by the interactions between domiphen bromide and amino acids/glycyl dipeptides. The mean aggregation number of domiphen bromide was determined by a fluorescence quenching method. Effects of temperature, concentration, and alkyl chain length of the amino acids/glycyl dipeptides on the above properties were examined. Amino acids and glycyl dipeptides effectively enhance the surface activity of domiphen bromide solution. The intensity of amino acid/dipeptide‐domiphen bromide interaction increased with the hydrophobicity of the amino acid/glycyl dipeptide.