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Antibacterial Activity of Alanine‐Derived Gemini Quaternary Ammonium Compounds
Author(s) -
Piecuch Agata,
Obłąk Ewa,
GuzRegner Katarzyna
Publication year - 2016
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1007/s11743-015-1778-3
Subject(s) - chemistry , alkyl , ammonium , antibacterial activity , antimicrobial , staphylococcus epidermidis , bromide , ammonium bromide , organic chemistry , nuclear chemistry , polymer chemistry , bacteria , staphylococcus aureus , biochemistry , pulmonary surfactant , genetics , biology
The antibacterial activity of alanine‐derived gemini quaternary ammonium salts (chlorides and bromides) with various spacer and alkyl chain lengths was investigated. The studied compounds exhibited a strong bactericidal effect, especially bromides with 10 and 12 carbon alkyl chains and 3 carbon spacer groups (TMPAL‐10 Br and TMPAL‐12 Br), with a short contact time. Both salts dislodged biofilms of Pseudomonas aeruginosa and Staphylococcus epidermidis , and were lethal to adherent cells of S. epidermidis. Bromide with 2 carbon spacer groups and 12 carbon alkyl chains (TMEAL‐12 Br) effectively reduced microbial adhesion by coating polystyrene and silicone surfaces. The results obtained suggest that, after further studies, gemini QAS might be considered as antimicrobial agents in medicine or industry.