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Optimization of Phospholipid Nanoparticle Formulations Using Response Surface Methodology
Author(s) -
Naeem Sumaira,
Kiew Lik Voon,
Chung Lip Yong,
Suk Vicit Rizal Eh,
Mahmood Asif,
Misran Misni Bin
Publication year - 2016
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1007/s11743-015-1757-8
Subject(s) - chemistry , dipalmitoylphosphatidylcholine , liposome , response surface methodology , lecithin , phospholipid , biocompatibility , particle size , nanoparticle , chromatography , vesicle , drug delivery , phosphatidylserine , solid lipid nanoparticle , chemical engineering , nanotechnology , phosphatidylcholine , organic chemistry , biochemistry , materials science , membrane , engineering
Abstract The present study deals with the optimization of phospholipid liposome formulations to mimic red blood cells. Optimization of different concentrations of distearylphosphatidylcholine, dipalmitoylphosphatidylcholine, and phosphatidylserine at a fixed concentration of lecithin and Tween ® 80 was done using response surface methodology. The optimized formulation produced liposomes with a particle size in the range of 112–196 nm. The optimized formulation shows low encapsulation efficiency at low levels of insulin but increases at higher loading levels. Formulated vesicles fulfill the size requirement for intravenous drug delivery. The present system is environmentally friendly with respect to biodegradability and biocompatibility.