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Surface Active Properties and Biological Activities of Novel Anionic Surfactant Based on Oxapyridazinone Derivatives
Author(s) -
ElShahawi Manal Mohamed,
Shalaby Alyaa Abou Sheashaa,
Gabre Adel Mohy ElDin,
Ghonim Abd ElHamed Mahmoud
Publication year - 2016
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1007/s11743-015-1756-9
Subject(s) - chemistry , chloroacetic acid , pulmonary surfactant , surface tension , hydrazide , acetic acid , acetic anhydride , sodium salt , molecule , organic chemistry , sodium , antimicrobial , nuclear chemistry , inorganic chemistry , catalysis , biochemistry , physics , quantum mechanics
A series of novel oxapyridazinone derivatives has been synthesized via cyclization of the corresponding sodium salt of α‐sulfonated fatty acid hydrazide with chloroacetic acid in the presence of sodium acetate and acetic anhydride. The structures of the prepared compounds were elucidated using different spectroscopic and elemental analysis. The surface properties (surface tension, CMC value and area per molecule), the thermodynamic stability and antimicrobial activities of the prepared compounds were determined and compared to standard trade material Texapone ® N‐70. The prepared compounds exhibit surface activity comparable to the standard and thus can be used as anionic surfactants.