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Mixed Micellization and Interfacial Properties of Ionic Liquid‐Type Imidazolium Gemini Surfactant with Amphiphilic Drug Amitriptyline Hydrochloride and its Thermodynamics
Author(s) -
Patel Rajan,
Khan Abbul Bashar,
Dohare Neeraj,
Maroof Ali Mohd.,
Rajor Hament Kumar
Publication year - 2015
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1007/s11743-015-1709-3
Subject(s) - chemistry , thermodynamics of micellization , mole fraction , gibbs free energy , gibbs isotherm , micelle , critical micelle concentration , thermodynamics , pulmonary surfactant , surface tension , standard molar entropy , adsorption , monolayer , aqueous solution , standard enthalpy of formation , biochemistry , physics
The thermodynamics of mixed micellization of amitriptyline hydrochloride (AMT) with ionic liquid‐type imidazolium gemini surfactant ([C 10 ‐4‐C 10 im] Br 2 ), was investigated at different mole fractions and temperatures by surface tension measurements. The deviation of the critical micelle concentration (CMC) from the ideal critical micelle concentration (CMC * ), micellar mole fraction ( X 1 m ) from ideal micellar mole fraction ( X 1 ideal ), the values of interaction parameter ( β ) and activity coefficients ( f i ) (for both mixed micelles and mixed monolayer) explained the non‐ideal behavior (i.e., synergistic behavior) of binary mixtures. The excess free energy (∆ G ex ) for the AMT‐[C 10 ‐4‐C 10 im] Br 2 binary mixtures explained the mixed micelles stability in comparison to micelles of [C 10 ‐4‐C 10 im] Br 2 and pure AMT. Interfacial parameters, i.e., Gibbs surface excess ( Γ max ), minimum head group area at air/water interface ( A min ), free energy of micellization ( Δ G m o ), and standard Gibbs energy of adsorption (∆ G ads o ) were also evaluated for the systems. The standard entropy of adsorption (∆ S ads o ) was found higher than the standard entropy of micellization (∆ S m o ) at all mole fractions of AMT ( α 1 ).