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Propoxylated Fatty Thiazole, Pyrazole, Triazole, and Pyrrole Derivatives with Antimicrobial and Surface Activity
Author(s) -
El-Sayed Refat,
Khairou Khalid S.
Publication year - 2015
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1007/s11743-015-1684-8
Subject(s) - chemistry , thiazole , lauric acid , pyrazole , antimicrobial , pyrrole , infrared spectroscopy , micelle , proton nmr , propylene oxide , 1,2,4 triazole , nuclear magnetic resonance spectroscopy , organic chemistry , nuclear chemistry , fatty acid , ethylene oxide , aqueous solution , copolymer , polymer
Abstract Lauric acid and propylene oxide were used to modify four biologically active heterocycles (thiazole, pyrazole, triazole, and pyrrole) to synthesize 17 new surfactants. The chemical structures of these surfactants were confirmed using infrared and 1 H, and 13 C nuclear magnetic resonance (NMR) spectroscopy. The surfactants all show good surface activity, low critical micelle concentration (CMC) values, high cloud points, and tight interfacial packing. All showed antimicrobial activity on both bacteria and fungi. In addition, biodegradation testing demonstrated significant breakdown within seven days.