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The Irritant Effects of Pharmaceutically Applied Surfactants
Author(s) -
Erős Gábor,
Kurgyis Zsuzsanna,
Németh István Balázs,
Csizmazia Eszter,
Berkó Szilvia,
SzabóRévész Piroska,
Kemény Lajos,
Csányi Erzsébet
Publication year - 2014
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1007/s11743-013-1444-6
Subject(s) - transepidermal water loss , chemistry , castor oil , irritation , irritant contact dermatitis , erythema , transdermal , chromatography , sucrose , dermatology , food science , pharmacology , contact dermatitis , organic chemistry , allergy , stratum corneum , medicine , pathology , immunology , biology
Dermal or transdermal medication may lead to irritant contact dermatitis. However, little information is available on the irritant effect of surfactants which are applied in topical formulations. Our aim was to examine the irritant effect of the most frequent compounds in topical products. A murine model was applied. The following compounds were examined: sodium lauryl sulphate (SLS), polyethoxylated (40EO) hydrogenated castor oil and sucrose laurate. SLS led to severe erythema, increase in transepidermal water loss (TEWL) and induced necrosis and accumulation of neutrophylic granulocytes and lymphocytes. Exposure to sucrose laurate resulted in an elevation of TEWL, but histology did not reveal impairment of the skin structure. Application of polyethoxylated (40EO) hydrogenated castor oil was not accompanied by tissue damage. Special attention should be paid to the irritant effect of SLS. Polyethoxylated (40EO) hydrogenated castor oil seems to be a non‐irritant agent and sucrose laurate is also a promising candidate for application in topical preparations.