Substituted Thiadiazole, Oxadiazole, Triazole and Triazinone as Antimicrobial and Surface Activity Compounds

Stearic acid ( 1 ) was utilized as a new cheap starting material in the manufacture of important biologically active heterocycles as thiadiazole, oxadiazole, triazole and triazinone derivatives ( 2 – 11 ) by treating with different nucleophiles. These heterocycles bears active hydrogen atom (SH, NH and NH 2 ) which could be propoxylated by different moles of propylene oxide (5, 10, 15 mol) to produce nonionic compounds ( 12 – 21 ) a – c having functions as surface and antimicrobial activities. The structural elucidation of these compounds is based on IR, 1 H NMR, 13 C NMR and elemental analysis. The surface properties (surface and interfacial tension, cloud point, witting time, foaming properties and emulsion stability) and the biodegradability were screened beside these compounds have been tested for their antimicrobial activity.