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Surface and Solution Properties of Amphiphilic Drug‐Nonionic Surfactant Systems
Author(s) -
Aldahbali Gamal A.,
Naqvi Andleeb Z.,
Akram Mohd.
Publication year - 2012
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1007/s11743-012-1352-1
Subject(s) - chemistry , pulmonary surfactant , monolayer , critical micelle concentration , mole fraction , micelle , gibbs free energy , gibbs isotherm , thermodynamics of micellization , ethylene oxide , surface tension , amphiphile , adsorption , organic chemistry , chemical engineering , thermodynamics , aqueous solution , copolymer , polymer , biochemistry , physics , engineering
A surface tension study was performed on mixed amphiphilic drug‐nonionic surfactant systems. The drugs used were adiphenine hydrochloride and nortriptyline hydrochloride whereas surfactants were ethoxylated sorbitan esters and polyethylene oxide–polypropylene oxide–polyethylene oxide triblocks. The critical micelle concentration (CMC) and CMC id (CMC at ideal mixing condition) values suggest nonideal and attractive interactions among the components. The micellar mole fraction ( X 1 m ) values calculated using Rubingh's model indicate predominance of the nonionic surfactant in micelle formation. The mole fraction of surfactant in mixed monolayer ( X 1 σ ) values are greater than X 1 m values, indicating a greater contribution of surfactant in monolayer formation. Thermodynamic parameters, viz. Gibbs energy of micellization ( G m o ) , Gibbs energy of adsorption ( G ad o ) , and excess free energy of mixed micelles ( G ex m ) and monolayers ( G ex σ ) were also evaluated. All these values suggest stable mixed micelle and mixed monolayer formation.