Open AccessIntestinal Electrical Stimulation Enhances Release of Postprandial Incretin Hormones Via Cholinergic Mechanisms
Author(s) -
Dong Yan,
Shujun Zhang,
Shiying Li,
Jiande D.Z. Chen
Publication year - 2021
Publication title -
obesity surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 138
eISSN - 1708-0428
pISSN - 0960-8923
DOI - 10.1007/s11695-021-05228-w
Subject(s) - postprandial , medicine , endocrinology , incretin , stimulation , atropine , glucagon like peptide 1 , antagonist , hormone , receptor , type 2 diabetes , diabetes mellitus , insulin
Intestinal electrical stimulation (IES) has been reported to reduce body weight and improve glucose tolerance in obese and diabetic rats. Our study aimed to investigate possible IES mechanisms involving incretin hormones using intraduodenal glucose infusion in rats. We hypothesized that the enhanced release of postprandial glucagon-like peptide-1 (GLP-1) at early phase by IES was mediated through neuro/paracrine mechanisms involving the vagal nerve and glucose-dependent insulinotropic peptide (GIP).