Open AccessLongitudinal Impacts of Gastric Bypass Surgery on Pharmacodynamics and Pharmacokinetics of Statins
Author(s) -
Asma El-Zailik,
Lily Cheung,
Yang Wang,
Vadim Sherman,
Diana Chow
Publication year - 2019
Publication title -
obesity surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 138
eISSN - 1708-0428
pISSN - 0960-8923
DOI - 10.1007/s11695-019-03885-6
Subject(s) - rosuvastatin , atorvastatin , simvastatin , medicine , pharmacokinetics , statin , pharmacology , pharmacodynamics , discontinuation , rosuvastatin calcium , dosing , active metabolite , urology , gastroenterology
Undergoing Roux-en-Y gastric bypass (RYGB) is expected to affect orally administered drug absorption. Statins are commonly prescribed to patients with obesity for the prevention of atherosclerotic cardiovascular diseases by lowering cholesterol. This is the first longitudinal prospective study on impacts of RYGB on weight loss, pharmacodynamics, and pharmacokinetics of atorvastatin, rosuvastatin, and simvastatin, and their active metabolites, up to 1-year post-surgery.