Open AccessBrain-predicted age difference score is related to specific cognitive functions: a multi-site replication analysis
Author(s) -
Rory Boyle,
Lee Jollans,
Laura M. RuedaDelgado,
Rossella Rizzo,
Goersev G. Yener,
Jason P. McMorrow,
Silvin P. Knight,
Daniel Carey,
Ian H. Robertson,
Derya Durusu EmekSavaş,
Yaakov Stern,
Rose Anne Kenny,
Robert Whelan
Publication year - 2020
Publication title -
brain imaging and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.239
H-Index - 50
eISSN - 1931-7565
pISSN - 1931-7557
DOI - 10.1007/s11682-020-00260-3
Subject(s) - cognition , neuropsychology , neuroimaging , psychology , neurocognitive , cognitive flexibility , fluency , developmental psychology , neuroscience , mathematics education
Brain-predicted age difference scores are calculated by subtracting chronological age from 'brain' age, which is estimated using neuroimaging data. Positive scores reflect accelerated ageing and are associated with increased mortality risk and poorer physical function. To date, however, the relationship between brain-predicted age difference scores and specific cognitive functions has not been systematically examined using appropriate statistical methods. First, applying machine learning to 1359 T1-weighted MRI scans, we predicted the relationship between chronological age and voxel-wise grey matter data. This model was then applied to MRI data from three independent datasets, significantly predicting chronological age in each dataset: Dokuz Eylül University (n = 175), the Cognitive Reserve/Reference Ability Neural Network study (n = 380), and The Irish Longitudinal Study on Ageing (n = 487). Each independent dataset had rich neuropsychological data. Brain-predicted age difference scores were significantly negatively correlated with performance on measures of general cognitive status (two datasets); processing speed, visual attention, and cognitive flexibility (three datasets); visual attention and cognitive flexibility (two datasets); and semantic verbal fluency (two datasets). As such, there is firm evidence of correlations between increased brain-predicted age differences and reduced cognitive function in some domains that are implicated in cognitive ageing.